Perspectives Pulmonary hypertension and nitric oxide depletion in sickle cell disease
نویسندگان
چکیده
1Division of Hematology, Department of Medicine, Harvard Medical School, Boston, MA; 2Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; 3Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD; 4Division of Hematology-Oncology-Transplantation, Department of Medicine, University of Minnesota School of Medicine, Minneapolis; 5Division of Laboratory Medicine, Children’s Hospital, Harvard Medical School, Boston, MA; 6Department of Medicine, Duke University School of Medicine, Durham, NC; and 7Department of Hematology, St Jude Children’s Research Hospital, Memphis TN
منابع مشابه
Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
During the past decade a large body of experimental and clinical studies has focused on the hypothesis that nitric oxide (NO) depletion by plasma hemoglobin in the microcirculation plays a central role in the pathogenesis of many manifestations of sickle cell disease (SCD), particularly pulmonary hypertension. We have carefully examined those studies and believe that the conclusions drawn from ...
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Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to pulmonary vasculopathy remain unclear. Transgenic mice provide opportunities for mechanistic studies of vascular pathophysiology in an animal model. By microcardiac catheterization, all mice expressing exclusively h...
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CONTEXT Sickle cell disease is characterized by a state of nitric oxide resistance and limited bioavailability of l-arginine, the substrate for nitric oxide synthesis. We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary hypertension, and patient outcomes. OBJECTIVE To explore the role of arginase in sickle cell...
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73/ Spring summer 2010, Vol.4, No. 1 Medical Laboratory Journal Correlation between Nitric oxide (NO) & Asymmetric dimethylargininie (ADMA) Hemoglobin Concentration in sickle cell patients Abstract Background and objectives: The importance of Nitric oxide (NO) and Asymmetric dimethylargininie (ADMA) in pathophysiology of Sickle cell disease (SCD) is being increasingly clarified. Since very few ...
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